These SIVs jumped from chimpanzees and sooty mangabeys to humans at least eleven times, giving rise to several strains of HIV lineages. HIV is a virulent pathogen in humans. SIVs, however, rarely cause any disease in chimpanzees, sooty mangabeys and dozens of other African primates species that SIVs naturally infects. This leads to the hypothesis that SIVs co-evolved with their non-human primate hosts for over hundreds of years.
Will we see a non-virulent HIV in the future as we infer the result of coevolution between SIVs and non-human primates? Will we solve the mystery of this coevolution,using its secrets to fight the HIV/AIDS pandemic?